Get ready for a hilarious fun-filled adventure starring Chloe (voice of Drew Barrymore) a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious life so much she hardly notices Papi (voice of George Lopez), a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch.

But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Shepherd (voice of Andy Garcia) to help her find her way home, Papi heads south of the border - joining forces with a motley crew: two humans (Piper Perabo, Manola Cardona), a sly rat (voice of Cheech Marin) and a nervous iguana (voice of Paul Rodriguez) - to rescue his true love.