This time around, their sights are set on one of the horror genre’s most popular subjects: werewolves. Set in an ultra-hip modern Los Angeles, the film tells the tale of siblings Ellie (Christina Ricci) and Jimmy (Jesse Eisenberg), who have yet to fully come to terms with the loss of their parents.

Ellie works at "The Late Late Show With Craig Kilborn" and dates ladies’ man Jake (Joshua Jackson), while Jimmy is a less-than-popular high school student with a crush on the prettiest girl in school (Kristina Anapau). But one night, after Ellie and Jimmy get into a car accident on Mulholland Drive, they are bitten by what appears to be a bona fide werewolf.

Soon, both brother and sister are exhibiting behavior that can only mean one thing--that they, too, have been cursed.