Set on and beneath the streets of London, "Flushed Away" is the story of Roddy, an upper-crust "society mouse," who is rather rudely evicted from his Kensington flat when he is flushed down into Ratropolis, the bustling sewer world found under London’s streets.

There, he meets Rita, an enterprising scavenger who works the sewers in her faithful boat, the Jammy Dodger.

Together they must navigate their way through a busy city filled with dangers for any mouse, including terrifying rapids, treacherous whirlpools and, most of all, the villainous Toad and his hench-rats Spike and Whitey.

Though completely out of his element at first, the privileged Roddy finds himself an unlikely hero when he learns that Ratropolis is in danger from the world above.